Neuro-Electronics Research Flanders

Nguyen TK, Navratilova Z, Cabral H, Wang L, Gielen G, Battaglia FP, Bartic C Closed-loop optical neural stimulation based on a 32-channel low-noise recording system with online spike sorting Journal of Neural Engineering 11(4):046005 (2014)

OBJECTIVE:
Closed-loop operation of neuro-electronic systems is desirable for both scientific and clinical (neuroprosthesis) applications. Integrating optical stimulation with recording capability further enhances the selectivity of neural stimulation. We have developed a system enabling the local delivery of optical stimuli and the simultaneous electrical measuring of the neural activities in a closed-loop approach.
APPROACH:
The signal analysis is performed online through the implementation of a template matching algorithm. The system performance is demonstrated with the recorded data and in awake rats.
MAIN RESULTS:
Specifically, the neural activities are simultaneously recorded, detected, classified online (through spike sorting) from 32 channels, and used to trigger a light emitting diode light source using generated TTL signals.
SIGNIFICANCE:
A total processing time of 8 ms is achieved, suitable for optogenetic studies of brain mechanisms online

PubMed link

http://www.ncbi.nlm.nih.gov/pubmed/24891498

DOI

10.1088/1741-2560/11/4/046005