Yaksi lab (NERF) collaboration with VIB Center for the Biology of Disease results in research article published in Journal of Cell Biology.
In this article the research team showed that loss of Rer1p resulted in the shortening of cilium and impairment of its motile or sensory function, which was reflected by hearing, vision, and left-right asymmetry defects as well as decreased Hedgehog signalling.
Source: Jurisch-Yaksi N, Rose AJ, Lu H, Raemaekers T, Munck S, Baatsen P, Baert V, Vermeire W, Scales SJ, Verleyen D, Vandepoel R, Tylzanowski P, Yaksi E, de Ravel T, Yost HJ, Froyen G, Arrington CB, Annaert W. Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels. J Cell Biol. (2013) Mar 18;200(6):709-20. doi: 10.1083/jcb.201208175. Epub 2013 Mar 11.